Endocrine Abstracts

Growth hormone-releasing hormone (GHRH), apart from stimulating GH secretion in the pituitary, exerts many extrapituitary functions, including stimulation of cell proliferation and survival. GHRH and its receptor splice variants (SVs) are expressed in different cancer cell types, where they modulate cell growth. It has been shown that GHRH antagonists exert anticancer activities in a variety of tumors, including malignant pleural mesothelioma and lung cancer, one of the leadin...

Growth hormone-releasing hormone (GHRH), apart from stimulating GH secretion in the pituitary, exerts many peripheral functions, including stimulation of cell proliferation and survival. In fact, GHRH and GHRH receptors (GHRH-Rs) are expressed in different cancer cell types, where they promote proliferation and survival. Conversely, GHRH antagonists exert antineoplastic activities in several tumors, including lung cancer, one of the leading causes of death by cancer worldwide....